How once-daily 2.5 mg Cialis compares with an as-needed 20 mg tablet

The recommended starting dose of tadalafil for once daily use in erectile dysfunction is 2.5 mg, taken at approximately the same time every day. The once daily dose may be increased to 5 mg based on individual efficacy and tolerability. Once daily tadalafil is taken without regard to the timing of sexual activity. Sexual stimulation is needed. Tadalafil may be taken with or without food. The BPH once-daily dose is 5 mg. That line is a different labelled indication from the 2.5 mg ED-daily start.

Do not combine CIALIS with other PDE5 inhibitors or other ED therapies. The maximum recommended dosing frequency is once per day. As-needed use and once-daily use are written as separate regimens.5 mg once daily. The weekend note locks the 20 mg as-needed step. Do not take a double dose of tadalafil to make up a missed dose. Do not split tadalafil tablets; the entire dose should be taken.

The recommended dose of tadalafil for once daily use for BPH is 5 mg, taken at approximately the same time every day. The recommended dose for once daily use for ED and BPH together is also 5 mg. When tadalafil is started with finasteride for BPH, 5 mg daily is recommended for up to 26 weeks. The incremental benefit of tadalafil beyond 26 weeks is unknown. Tadalafil is not recommended in combination with other alpha-blockers for the treatment of BPH. Patients on an alpha-blocker for BPH should discontinue the alpha-blocker at least one day prior to starting once daily tadalafil for BPH.

The mean terminal half-life is 17.5 hours in healthy subjects. After a dose, the maximum tadalafil concentration is reached between 30 minutes and 6 hours. The median time to maximum concentration is about 2 hours. In trials of CIALIS for once daily use, a total of 1434, 905, and 115 were treated for at least 6 months, 1 year, and 2 years, respectively. At a dose of 5 mg, the incidence and severity of back pain was not significantly different than in the general population in the cited pharmacology text.

CIALIS may be taken without regard to food. Rate and extent of tadalafil absorption are not influenced by food. Once daily tadalafil is taken without regard to the timing of sexual activity. The recommended starting dose of tadalafil for once daily use in erectile dysfunction is 2.5 mg, taken at approximately the same time every day. The once daily dose may be increased to 5 mg based on individual efficacy and tolerability. Sexual stimulation is needed. Do not split tadalafil tablets; the entire dose should be taken. Store at 25 C (77 F); excursions permitted to 15 to 30 C (59 to 86 F).

In three placebo-controlled clinical trials of 12 weeks duration for once-daily ED, headache occurred in 3% at 2.5 mg, 6% at 5 mg, and 5% on placebo. Dyspepsia occurred in 4% at 2.5 mg, 5% at 5 mg, and 2% on placebo. Back pain occurred in 3% at 2.5 mg, 3% at 5 mg, and 1% on placebo. Myalgia occurred in 2% at 2.5 mg, 2% at 5 mg, and 1% on placebo. Nasal congestion occurred in 2% at 2.5 mg, 2% at 5 mg, and 0% on placebo. Flushing occurred in 1% at 2.5 mg, 3% at 5 mg, and 1% on placebo. In trials of CIALIS for once daily use, a total of 1434, 905, and 115 were treated for at least 6 months, 1 year, and 2 years, respectively.

If you miss a dose, you may take it when you remember but do not take more than one dose per day. Do not take a double dose of tadalafil to make up a missed dose. CIALIS for once daily use in erectile dysfunction starts at 2.5 mg, taken at approximately the same time every day. The mean terminal half-life is 17.5 hours in healthy subjects. Keep out of reach of children.