A high-fat meal can delay how fast the 100 mg Viagra tablet works

VIAGRA may be taken anywhere from 30 minutes to 4 hours before sexual activity. Most studies assessed the efficacy of VIAGRA approximately 60 minutes post dose. A high-fat meal can delay how fast sildenafil works. Sexual stimulation is required. The maximum recommended dosing frequency is once per day. The prescriber names the hour.

Both sildenafil and the metabolite have terminal half lives of about 4 hours. The pharmacokinetics of sildenafil are dose-proportional over the recommended dose range. The recommended starting dose of sildenafil for most patients is 50 mg. The dose may be increased to a maximum recommended dose of 100 mg or decreased to 25 mg. A high-fat meal can delay how fast sildenafil works. That delay is a timing fact, not a new half-life.

The maximum recommended dosing frequency is once per day. The maximum recommended dose of sildenafil is 100 mg. Sildenafil is contraindicated in patients using any form of organic nitrate, either regularly or intermittently. Do not combine with other PDE5 inhibitors.

Viagra is not indicated for women. Viagra is indicated for erectile dysfunction. Sexual stimulation is required. There was no effect on sperm motility or morphology after single 100 mg oral doses of VIAGRA in healthy volunteers. Store at 25 C (77 F); excursions permitted to 15 to 30 C (59 to 86 F).

VIAGRA is rapidly absorbed. Maximum observed plasma concentrations are reached within 30 to 120 minutes (median 60 minutes) of oral dosing in the fasted state. When VIAGRA is taken with a high fat meal, the rate of absorption is reduced, with a mean delay in Tmax of 60 minutes. Both sildenafil and the metabolite have terminal half lives of about 4 hours. The mean steady state volume of distribution (Vss) for sildenafil is 105 L, indicating distribution into the tissues. Sildenafil and its major circulating N-desmethyl metabolite are both approximately 96% bound to plasma proteins. Protein binding is independent of total drug concentrations.

There was no effect on sperm motility or morphology after single 100 mg oral doses of VIAGRA in healthy volunteers. The pharmacokinetics of sildenafil are dose-proportional over the recommended dose range. Single oral doses of sildenafil up to 100 mg produced no clinically relevant changes in the ECGs of normal male volunteers. Viagra is indicated for erectile dysfunction. Sexual stimulation is required. The maximum recommended dosing frequency is once per day.

Sildenafil is contraindicated in patients using any form of organic nitrate, either regularly or intermittently. Nitrates include nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, and amyl nitrite. Administration of VIAGRA to patients using nitric oxide donors, such as organic nitrates or organic nitrites in any form, is contraindicated. Consistent with its known effects on the nitric oxide/cGMP pathway, VIAGRA was shown to potentiate the hypotensive effects of nitrates. VIAGRA is contraindicated in patients with a known hypersensitivity to sildenafil or any component of the tablet. Hypersensitivity reactions have been reported, including rash and urticaria.

The mean steady state volume of distribution (Vss) for sildenafil is 105 L, indicating distribution into the tissues. Sildenafil and its major circulating N-desmethyl metabolite are both approximately 96% bound to plasma proteins. Protein binding is independent of total drug concentrations. Both sildenafil and the metabolite have terminal half lives of about 4 hours. The pharmacokinetics of sildenafil are dose-proportional over the recommended dose range. The maximum recommended dose of sildenafil is 100 mg. The maximum recommended dosing frequency is once per day.

VIAGRA is supplied as blue, film-coated, rounded-diamond-shaped tablets. VIAGRA tablets contain sildenafil citrate equivalent to 25 mg, 50 mg, or 100 mg of sildenafil. Store at 25 C (77 F); excursions permitted to 15 to 30 C (59 to 86 F). Viagra is indicated for erectile dysfunction. Sexual stimulation is required.