Synthroid 75 mcg is taken once a day on an empty stomach

01What SYNTHROID is labelled for

SYNTHROID is indicated as replacement therapy in primary, secondary, and tertiary hypothyroidism. SYNTHROID is not indicated for suppression of benign thyroid nodules or for weight loss. Do not use SYNTHROID for the treatment of obesity or for weight loss. Doses within the range of daily hormonal requirements are ineffective for weight reduction.

02The 4-hour gap, TSH clock, and dose steps

SYNTHROID should be taken at least 4 hours apart from drugs that are known to interfere with its absorption. Iron and calcium supplements and antacids can decrease levothyroxine absorption. Instruct patients not to take SYNTHROID tablets within 4 hours of these agents.

In adult patients with primary hypothyroidism, monitor serum TSH levels after an interval of 6 to 8 weeks after any change in dose. The peak therapeutic effect of a given dose of SYNTHROID may not be attained for 4 to 6 weeks. On a stable replacement dose, evaluate clinical and biochemical response every 6 to 12 months and whenever there is a change in the patient's clinical status.

The dose of SYNTHROID for hypothyroidism depends on age, body weight, cardiovascular status, pregnancy, other medicines, food taken with the tablet, and the condition being treated. Dosing is individualized. Dose adjustments follow the clinical response and the laboratory numbers.

Start SYNTHROID at the full replacement dose in otherwise healthy, non-elderly individuals. A full replacement dose is 1.6 mcg per kg body weight per day. Adjust the dose by 12.5 to 25 mcg increments every 4 to 6 weeks until the patient is clinically euthyroid and the serum TSH returns to normal. Doses greater than 200 mcg per day are seldom required. An inadequate response to daily doses greater than 300 mcg per day is rare and may indicate poor compliance, malabsorption, drug interactions, or a combination of these factors.

For elderly patients or patients with underlying cardiac disease, start with a dose of 12.5 to 25 mcg per day. Increase the dose every 6 to 8 weeks, as needed, until the patient is clinically euthyroid and the serum TSH returns to normal. The full replacement dose of SYNTHROID may be less than 1 mcg per kg per day in elderly patients.

In patients with severe longstanding hypothyroidism, start with a dose of 12.5 to 25 mcg per day. Adjust the dose in 12.5 to 25 mcg increments every 2 to 4 weeks until the patient is clinically euthyroid and the serum TSH level is normalized.

Serum TSH is not a reliable measure of SYNTHROID dose adequacy in patients with secondary or tertiary hypothyroidism. Use the serum free-T4 level to monitor adequacy of therapy in that population. Titrate until the patient is clinically euthyroid and the serum free-T4 level is restored to the upper half of the normal range.

SYNTHROID dose requirements may increase during pregnancy. Measure serum TSH and free-T4 as soon as pregnancy is confirmed and, at minimum, during each trimester. In patients with primary hypothyroidism, maintain serum TSH in the trimester-specific reference range. For patients with serum TSH above the normal trimester-specific range, increase the dose of SYNTHROID by 12.5 to 25 mcg per day and measure TSH every 4 weeks until a stable SYNTHROID dose is reached and serum TSH is within the normal trimester-specific range. Reduce SYNTHROID dosage to pre-pregnancy levels immediately after delivery and measure serum TSH levels 4 to 8 weeks postpartum.

SYNTHROID should not be discontinued during pregnancy. Hypothyroidism diagnosed during pregnancy should be promptly treated.

Circulating thyroid hormones are greater than 99 percent bound to plasma proteins, including thyroxine-binding globulin, thyroxine-binding prealbumin, and albumin. Only unbound hormone is metabolically active. The higher affinity of the binding proteins for T4 helps explain the slower clearance and the longer half-life of T4 compared with T3.

It may take several weeks before a patient notices an improvement in symptoms. Adequacy of therapy is determined with periodic monitoring of TSH and, when TSH cannot be used, free-T4, together with the clinical status.

03A 75 mcg count at the U.S. window

Generic levothyroxine 75 mcg, ninety tablets, the Halo empty-stomach lock, October 2026. GoodRx lists 75 mcg x 90 at $10.00 retail and $10.00 with a coupon. Ask the window to price thirty if that is the script. Take on an empty stomach. Halo does not dispense.

A 75 mcg SYNTHROID tablet is one labelled replacement strength.